化学科のみなさま

6月5日（水）16時30分より講演会を開催します。

講師：Prof. Ye ZHU

(National University of Singapore)

講演題目： Electrostatic interactions enable remote stereocontrol in palladium-catalyzed cross-coupling

場所：南7号館1階101室
講演概要：Incorporating ionic groups into synthetic transition-metal catalysts represents a promising design element for enantioselective reactions. However, the nondirectional nature of ionic interactions presents a unique challenge in the precise transmission of chirality from the catalysts to the prochiral substrates. In this talk, I will present our recent work on innovating three generations of phosphine ligands possessing nonligating ionic groups to exert long-range stereocontrol in Pd-catalyzed cross-coupling reactions. The applications of the ionic ligand–substrate interaction strategy in enantiotopic-group-selective reactions and atroposelective reactions to access quaternary carbon, triaryl phosphorus, axial biaryls, mechanically planar chiral rotaxanes, and inherently chiral cavitands will be discussed to illustrate the synthetic utilities. In addition, experimental and computational mechanistic studies reveal unconventional combinations of electrostatic steering and electrostatic catalysis by the oriented internal electric field produced by the ionic ligand–substrate interactions.

 

Zhu教授は，不斉触媒反応の開発研究で顕著な業績をあげています。今回，Asian Core Program Awardを受賞されて来日され，最新の研究成果についてご講演いただきます。

 

多数の皆様のご参加をお待ちしています。

秋山

06-05_Zhu講演会ポスター